Welcome to the Sreedharan lab! We are a dedicated group of researchers focused on investigating the underlying mechanisms of neurodegenerative diseases, with specific emphasis on amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Our mission is to uncover new insights and potential therapies that can ultimately lead to better treatments and management for these devastating conditions.
Whether you are a fellow researcher, a student, or simply curious about science, we invite you to explore our website. We hope that you will find it informative and inspiring, and we look forward to sharing our discoveries with you.
Neurodegeneration Research in the Sreedharan Lab
We study amyotrophic lateral sclerosis (ALS) and the overlapping condition frontotemporal dementia (FTD) particularly focusing on TDP-43 pathology. Almost all ALS and half of FTD cases demonstrate disturbances in the DNA/RNA binding protein TDP-43.
We use genetic engineering technologies to create knock-in models, such as iPSC derived disease models and in vivo models, that we believe more accurately reflect the processes actually occurring in disease.
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We have a particular interest in axon degeneration pathways linked to SARM1. Axons and synapses are particularly vulnerable in the earliest stages of neurodegenerative disease and protecting these vital structures is important to maintaining a healthy and functioning nervous system.
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